期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 10, 页码 710-718出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2914
关键词
-
资金
- Wellcome Trust [089647/Z/09/Z]
- Biotechnology and Biological Sciences Research Council
- Neuroendocrine Charitable Trust
- Biotechnology and Biological Sciences Research Council [BB/H015779/1] Funding Source: researchfish
- BBSRC [BB/H015779/1] Funding Source: UKRI
- Wellcome Trust [089647/Z/09/Z] Funding Source: Wellcome Trust
The classical concept of hypothalamus-pituitary-adrenal (HPA) homeostasis comprises a feedback system within which circulating levels of glucocorticoid hormones maintain the brain and body in an optimal steady state. However, studies involving new techniques for investigating the real-time dynamics of both glucocorticoid hormones and glucocorticoid receptor function paint a different picture-namely, of continuous dynamic equilibration throughout this neuroendocrine system. This dynamic state is dictated by feedforward and feedback regulatory loops and by stochastic interactions at the level of DNA binding. We propose that this continuous oscillatory activity is crucial for optimal responsiveness of glucocorticoid-sensitive neural processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据