期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 7, 页码 459-473出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2867
关键词
-
资金
- Medical Research Council
- Royal Society
- Natural Sciences and Engineering Research Council of Canada
- National Alliance for Research on Schizophrenia and Depression
- Saskatchewan Health Research Foundation
- Canada Foundation for Innovation
- Canadian Institutes for Health Research
- Howard Hughes Medical Institute
- Heart and Stroke Foundation of British Columbia
- Yukon Chair in Stroke Research
- MRC [G0601813] Funding Source: UKRI
- National Research Foundation of Korea [R31-2008-000-10089-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Medical Research Council [G0601813] Funding Source: researchfish
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled. Most studies have focused on forms of LTD that are triggered by synaptic activation of either NMDARs (N-methyl-d-aspartate receptors) or metabotropic glutamate receptors (mGluRs). Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response. In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据