期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 6, 页码 402-416出版社
NATURE PORTFOLIO
DOI: 10.1038/nrn2841
关键词
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资金
- US National Institutes of Health [R01MH67068, R01HD42974]
- Simons Foundation
- McKnight and March of Dimes Foundations
Recent studies are beginning to paint a clear and consistent picture of the impairments in psychological and cognitive competencies that are associated with microdeletions in chromosome 22q11.2. These studies have highlighted a strong link between this genetic lesion and schizophrenia. Parallel studies in humans and animal models are starting to uncover the complex genetic and neural substrates altered by the microdeletion. In addition to offering a deeper understanding of the effects of this genetic lesion, these findings may guide analysis of other copy-number variants associated with cognitive dysfunction and psychiatric disorders.
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