期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 5, 页码 301-315出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2834
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资金
- McKnight Endowment Fund for Neuroscience
- Human Frontiers Science Foundation
- NARSAD
- Swiss National Science Foundation
- National Institute of Neurological Disorders and Stroke [R01 NS37682]
- National Institute on Drug Abuse [R01 DA019022]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS037682] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA019022] Funding Source: NIH RePORTER
G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission. GIRK channel function and trafficking are highly dependent on the channel subunit composition. Pharmacological investigations of GIRK channels and studies in animal models suggest that GIRK activity has an important role in physiological responses, including pain perception and memory modulation. Moreover, abnormal GIRK function has been implicated in altering neuronal excitability and cell death, which may be important in the pathophysiology of diseases such as epilepsy, Down's syndrome, Parkinson's disease and drug addiction. GIRK channels may therefore prove to be a valuable new therapeutic target.
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