期刊
NATURE REVIEWS NEUROSCIENCE
卷 11, 期 12, 页码 799-811出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2936
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资金
- Swiss National Science Foundation [3100AO- 122,527/1]
- National Center for Competence in Research 'Neural Plasticity & Repair' of the Swiss National Science Foundation
- Spinal Cord Consortium of the Christopher and Dana Reeve Foundation
- EU
- International Foundation of Research in Paraplegia
The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and their receptors - in precursor migration, neurite growth and branching in the developing nervous system - as well as a growth-restricting function during CNS maturation. The function of Nogo in the adult CNS is now understood to be that of a negative regulator of neuronal growth, leading to stabilization of the CNS wiring at the expense of extensive plastic rearrangements and regeneration after injury. In addition, Nogo proteins interact with various intracellular components and may have roles in the regulation of endoplasmic reticulum (ER) structure, processing of amyloid precursor protein and cell survival.
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