期刊
NATURE REVIEWS NEUROSCIENCE
卷 10, 期 6, 页码 397-409出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2647
关键词
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资金
- US National Institutes of Health [MH049698, MH069860, MH069725, AG12962, DK078906]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K01DK078906] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R29MH049698, R01MH069725, R01MH049698, R01MH069860] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG012962] Funding Source: NIH RePORTER
The survival and well-being of all species requires appropriate physiological responses to environmental and homeostatic challenges. The re-establishment and maintenance of homeostasis entails the coordinated activation and control of neuroendocrine and autonomic stress systems. These collective stress responses are mediated by largely overlapping circuits in the limbic forebrain, the hypothalamus and the brainstem, so that the respective contributions of the neuroendocrine and autonomic systems are tuned in accordance with stressor modality and intensity. Limbic regions that are responsible for regulating stress responses intersect with circuits that are responsible for memory and reward, providing a means to tailor the stress response with respect to prior experience and anticipated outcomes.
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