期刊
NATURE REVIEWS NEUROSCIENCE
卷 9, 期 2, 页码 136-147出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2236
关键词
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资金
- NINDS NIH HHS [NS40371, R01 NS040371, NS48660] Funding Source: Medline
Higher-order actin-based networks (actin superstructures) are important for growth-cone motility and guidance. Principles for generating, organizing and remodelling actin superstructures have emerged from recent findings in cell-free systems, non-neuronal cells and growth cones. This Review examines how actin superstructures are initiated de novo at the leading-edge membrane and how the spontaneous organization of actin superstructures is driven by ensembles of actin-binding proteins. How the regulation of actin-binding proteins can affect growth-cone turning and axonal regeneration is also discussed.
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