期刊
NATURE REVIEWS NEUROSCIENCE
卷 9, 期 10, 页码 768-778出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2494
关键词
-
资金
- National Institute on Aging [5R01AG23667]
- National Institute of Mental Health [5R37MH60009]
- Cure Alzheimer's Fund
- NATIONAL INSTITUTE OF MENTAL HEALTH [R37MH060009] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG023667] Funding Source: NIH RePORTER
The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early successes in identifying three genes that cause early-onset familial AD (those that encode amyloid precursor protein (APP) and the presenilins (PSEN1 and PSEN2)), and one genetic risk factor for late-onset AD (the gene that encodes apolipoprotein E (APOE)). A large number of studies that aimed to help uncover the remaining disease-related loci have been published in recent decades, collectively proposing or refuting the involvement of over 500 different gene candidates. Systematic meta-analyses of these studies currently highlight more than 20 loci that have modest but significant effects on AD risk. This Review discusses the putative pathogenetic roles and common biochemical pathways of some of the most genetically and biologically compelling of these potential AD risk factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据