期刊
NATURE REVIEWS NEPHROLOGY
卷 10, 期 1, 页码 14-24出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneph.2013.183
关键词
-
资金
- Scott M. Krummey, Emory University
- [R01 AI073707]
- [R01 AI104699]
- [U19 AI1051731]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI104699, R01AI073707] Funding Source: NIH RePORTER
The myriad of co-stimulatory signals expressed, or induced, upon T-cell activation suggests that these signalling pathways shape the character and magnitude of the resulting autoreactive or alloreactive T-cell responses during autoimmunity or transplantation, respectively. Reducing pathological T-cell responses by targeting T-cell co-stimulatory pathways has met with therapeutic success in many instances, but challenges remain. In this Review, we discuss the T-cell co-stimulatory molecules that are known to have critical roles during T-cell activation, expansion, and differentiation. We also outline the functional importance of T-cell co-stimulatory molecules in transplantation, tolerance and autoimmunity, and we describe how therapeutic blockade of these pathways might be harnessed to manipulate the immune response to prevent or attenuate pathological immune responses. Ultimately, understanding the interplay between individual co-stimulatory and co-inhibitory pathways engaged during T-cell activation and differentiation will lead to rational and targeted therapeutic interventions to manipulate T-cell responses and improve clinical outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据