期刊
SOCIAL NEUROSCIENCE
卷 11, 期 3, 页码 249-263出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/17470919.2015.1072582
关键词
Glutamine; Perigenual anterior cingulate cortex; MRS; EEG; Self-referential processing
资金
- CIHR
- EJLB-CIHR
- ISAN/HDRF
- JSPS [24390284, 25870467, 26285168]
- Taiwan's National Science Council [100-2410-H-004-139-MY3, 102-2420-H-038-002-MY2]
- National Chengchi University's Research Center for Mind, Brain, and Learning
- Grants-in-Aid for Scientific Research [25870467, 26285168, 24390284] Funding Source: KAKEN
Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This rest-self overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects' perception (and judgment) of subsequent stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli.
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