期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 19, 期 11, 页码 713-730出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-018-0052-8
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资金
- Italian Ministry of Education, University and Research
- Italian Ministry of Health
- Telethon [GGP15219/B]
- Italian Association for Cancer Research [AIRC IG-19803, AIRC IG-18624]
- University of Ferrara
- Fondazione Cariplo grant
- Fondazione Umberto Veronesi
Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they have many physiological functions, prominently including muscle contraction, neuronal excitability, cell migration and cell growth. By sequestering and releasing Ca2+, mitochondria serve as important regulators of cellular Ca2+. Mitochondrial Ca2+ also has other important functions, such as regulation of mitochondrial metabolism, ATP production and cell death. In recent years, identification of the molecular machinery regulating mitochondrial Ca2+ accumulation and efflux has expanded the number of (patho) physiological conditions that rely on mitochondrial Ca2+ homeostasis. Thus, expanding the understanding of the mechanisms of mitochondrial Ca2+ regulation and function in different cell types is an important task in biomedical research, which offers the possibility of targeting mitochondrial Ca2+ machinery for the treatment of several disorders.
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