期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 15, 期 3, 页码 211-217出版社
NATURE PORTFOLIO
DOI: 10.1038/nrm3752
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资金
- Ellison Medical Foundation/American Federation for Aging Research (AFAR)
- US NIH [R01 AG042679]
Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications.
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