期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 15, 期 1, 页码 65-74出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3716
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资金
- Karolinska Institute Foundation
- US National Institute of Health (NIH) [GM53396]
- Swedish Cancer Society
- Swedish Childhood Cancer Foundation
- Swedish Research Council
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM053396] Funding Source: NIH RePORTER
Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigenetic network that regulates autophagy. The identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3), microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and dimethylated H3K9 (H3K9me2)) associated with the autophagic process offers an attractive conceptual framework to understand the short-term transcriptional response and potential long-term responses to autophagy.
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