期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 14, 期 1, 页码 25-37出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3494
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资金
- NIGMS NIH HHS [R01 GM098579, GM98579] Funding Source: Medline
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase-phosphatase signalling and the microtubule-binding KMN protein network.
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