期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 14, 期 3, 页码 133-139出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3522
关键词
-
类别
资金
- National Institutes of Health (NIH) [CA108941]
- Department of Defense [W81XWH-09-1-0279]
- National Cancer Institute [T32CA121938]
- Canadian Institute of Health Research (CIHR)
Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that is part of mTOR complex 1 (mTORC1), a master regulator that couples amino acid availability to cell growth and autophagy. Multiple cues modulate mTORC1 activity, such as growth factors, stress, energy status and amino acids. Although amino acids are key environmental stimuli, exactly how they are sensed and how they activate mTORC1 is not fully understood. Recently, a model has emerged whereby mTORC1 activation occurs at the lysosome and is mediated through an amino acid sensing cascade involving RAG GTPases, Ragulator and vacuolar H+-ATPase (v-ATPase).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据