期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 13, 期 9, 页码 566-578出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3412
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资金
- Italian Ministry of Health
- Italian Ministry of Education, Universities and Research
- European Union (ERC mitoCalcium) [294777]
- European Union (FP7 'MyoAGE') [223576]
- US National Institues of Health (NIH) [1P01AG025532-01A1]
- Cariparo Foundation (Padua)
- Italian Association for Cancer Research (AIRC)
- Telethon-Italy [GPP10005A, GGP11082B]
During the past two decades calcium (Ca2+) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+ uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca2+ levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca2+ transporters has been revealed, opening new perspectives for investigation and molecular intervention.
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