期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 13, 期 3, 页码 141-152出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3289
关键词
-
类别
资金
- Medical Research Council, Association for International Cancer Research
- Fanconi Anaemia Research Fund
- Medical Research Council
- NICHD/NIH
- MRC [MC_U105178808, G0501450] Funding Source: UKRI
- Medical Research Council [G0801130B, G0501450, MC_U105178808] Funding Source: researchfish
- Worldwide Cancer Research [11-0514] Funding Source: researchfish
The past 15 years have seen an explosion in our understanding of how cells replicate damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at the heart of this process, which is commonly known as translesion synthesis. This family of polymerases has unique features that enable them to synthesize DNA past damaged bases. However, as they exhibit low fidelity when copying undamaged DNA, it is essential that they are only called into play when they are absolutely required. Several layers of regulation ensure that this is achieved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据