期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 13, 期 7, 页码 425-435出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3373
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资金
- Swiss Cancer League [02584-02-2010]
- Swiss National Science Foundation [CRSII3_125463]
- European Research Council (ERC) [AdG 233335]
- Swiss National Science Foundation (SNF) [CRSII3_125463] Funding Source: Swiss National Science Foundation (SNF)
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function.
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