期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 13, 期 10, 页码 673-679出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3431
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资金
- National Health and Medical Research Council of Australia [APP1010489, 631383]
- Australian Research Council [DP 0988935]
- Kids Cancer Project of the Oncology Children's Foundation
- Human Frontiers Science Program
Classical cadherin adhesion receptors influence tissue integrity in health and disease. Their biological function is intimately linked to the actin cytoskeleton. To date, research has largely focused on identifying the molecular mechanisms that physically couple cadherin to cortical actin filaments. However, the junctional cytoskeleton is dynamic. Recent developments in understanding how filament dynamics and organization in the junctional cytoskeleton are controlled provide new insights into how the actin cytoskeleton regulates cadherin junctions in health and disease.
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