期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 13, 期 8, 页码 489-498出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3392
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- UK Medical Research Council (MRC) [U105178780]
- Medical Research Council [MC_U105178780] Funding Source: researchfish
- MRC [MC_U105178780] Funding Source: UKRI
Large-scale sequencing of genomes has revealed that most enzyme families include inactive homologues. These pseudoenzymes are often well conserved, implying a selective pressure to retain them during evolution, and therefore that they have significant function. Mechanistic insights and evolutionary lessons are now emerging from the study of a broad range of such 'dead' enzymes. The recently discovered iRhoms - inactive homologues of rhomboid proteases - have joined derlins and other members of the rhomboid-like clan in regulating the fate of proteins as they pass through the secretory pathway. There is a strong case that dead enzymes, which have been rather overlooked, may be a rich source of biological regulators.
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