期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 13, 期 1, 页码 27-38出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3254
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资金
- US National Institutes of Health [AR055923, DK065789, AR060456]
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060456, R01AR055923] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK065789] Funding Source: NIH RePORTER
The past 15 years have witnessed tremendous progress in the molecular understanding of osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the major developmental signals (including WNT and Notch signalling), along with an increasing number of transcription factors (such as RUNX2 and osterix), have been shown to regulate the differentiation and/or function of osteoblasts. As evidence indicates that osteoblasts may also regulate the behaviour of other cell types, a clear understanding of the molecular identity and regulation of osteoblasts is important beyond the field of bone biology.
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