期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 12, 期 8, 页码 483-492出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3152
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资金
- US National Institutes of Health [GM077590]
- Monsanto Company
In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the myriad RNAs that are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, which orchestrate non-coding RNA-mediated gene silencing processes affecting development, transposon taming, antiviral defence and allelic crosstalk. Biochemical details concerning the templates and products of RNA polymerases IV and V are lacking. However, their subunit compositions reveal that they evolved as specialized forms of RNA polymerase II, which provides the unique opportunity to study the functional diversification of a eukaryotic RNA polymerase family.
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