期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 12, 期 1, 页码 14-20出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3029
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- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM029362] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM029362, R01 GM029362-29] Funding Source: Medline
Mitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with imported subunits that are encoded in the nucleus. New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex.
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