期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 11, 期 4, 页码 237-251出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2867
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资金
- Leukemia and Lymphoma Society
- NIH/NIGMS [RO1-GM059609]
- NIH/NIAID [RO1-AI074760]
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-promoting factors and formins were the only molecules known to directly nucleate actin filament formation de novo. However, the past several years have seen a surge in the discovery of mammalian proteins with roles in actin nucleation and dynamics. Newly recognized nucleation-promoting factors, such as WASP and SCAR homologue (WASH), WASP homologue associated with actin, membranes and microtubules (WHAMM), and junction-mediating regulatory protein (JMY), stimulate ARP2/3 activity at distinct cellular locations. Formin nucleators with additional biochemical and cellular activities have also been uncovered. Finally, the Spire, cordon-bleu and leiomodin nucleators have revealed new ways of overcoming the kinetic barriers to actin polymerization.
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