期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 11, 期 11, 页码 764-776出版社
NATURE RESEARCH
DOI: 10.1038/nrm2995
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资金
- US National Institutes of Health [R01 MH051573, R01 GM074868, RO1 GM056006, RO1 GM067837, RO1 GM092412]
An intrinsic clock enables an organism to anticipate environmental changes and use energy sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock to orchestrate rhythms is also important for human health. The use of systems biology approaches has advanced our understanding of mechanistic features of circadian oscillators over the past decade. The field is now in a position to develop a multiscale view of circadian systems, from the molecular level to the intact organism, and to apply this information for the development of new therapeutic strategies or for enhancing agricultural productivity in crops.
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