期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 10, 期 1, 页码 63-73出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2597
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资金
- National Institutes of Health [HL082792, NS059348]
- American Heart Association [0635359N]
- Progeria Research Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL082792] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS059348] Funding Source: NIH RePORTER
Cells sense their physical surroundings through mechanotransduction - that is, by translating mechanical forces and deformations into biochemical signals such as changes in intracellular calcium concentration or by activating diverse signalling pathways. In turn, these signals can adjust cellular and extracellular structure. This mechanosensitive feedback modulates cellular functions as diverse as migration, proliferation, differentiation and apoptosis, and is crucial for organ development and homeostasis. Consequently, defects in mechanotransduction - often caused by mutations or misregulation of proteins that disturb cellular or extracellular mechanics - are implicated in the development of various diseases, ranging from muscular dystrophies and cardiomyopathies to cancer progression and metastasis.
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