期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 10, 期 2, 页码 116-125出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2621
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资金
- National Institutes of Health [HD33760, HD37760S1, HD42042]
- Connecticut Stem Cell Research Fund
- G. Harold and Leila Mathers Foundation
- Stem Cell Research Foundation
The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated cells. This unique property is controlled by dynamic interplays between extrinsic signalling, epigenetic, transcriptional and post-transcriptional regulations. Recent research indicates that microRNAs (miRNAs) have an important role in regulating stem cell self-renewal and differentiation by repressing the translation of selected mRNAs in stem cells and differentiating daughter cells. Such a role has been shown in embryonic stem cells, germline stem cells and various somatic tissue stem cells. These findings reveal a new dimension of gene regulation in controlling stem cell fate and behaviour.
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