期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 11, 期 2, 页码 138-148出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2831
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类别
资金
- National Institutes of Health [CA089239, CA092312, CA100109]
- Department of Anatomy, The University of Hong Kong
- Department of Defence [P50 CA116201]
The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.
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