期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 10, 期 9, 页码 644-650出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2746
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资金
- Natural Sciences and Engineering Research Council of Canada
- National Institutes of Health
- Nanomedicine Development Centre
We are much better at taking cells apart than putting them together. Reconstitution of biological processes from component molecules has been a powerful but difficult approach to studying functional organization in biology. Recently, the convergence of biochemical and cell biological advances with new experimental and computational tools is providing the opportunity to reconstitute increasingly complex processes. We predict that this bottom-up strategy will uncover basic processes that guide cellular assembly, advancing both basic and applied sciences.
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