期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 9, 期 2, 页码 112-124出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2330
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资金
- NIGMS NIH HHS [R01 GM077198, R01 GM077198-02] Funding Source: Medline
Throughout the biological world, a 30 angstrom hydrophobic film typically delimits the environments that serve as the margin between life and death for individual cells. Biochemical and biophysical findings have provided a detailed model of the composition and structure of membranes, which includes levels of dynamic organization both across the lipid bilayer ( lipid asymmetry) and in the lateral dimension ( lipid domains) of membranes. How do cells apply anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of their individual membranes?.
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