期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 9, 期 1, 页码 22-32出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2321
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- Wellcome Trust [076624] Funding Source: Medline
During the past decade, small non-coding RNAs have rapidly emerged as important contributors to gene regulation. To carry out their biological functions, these small RNAs require a unique class of proteins called Argonautes. The discovery and our comprehension of this highly conserved protein family is closely linked to the study of RNAbased gene silencing mechanisms. With their functional domains, Argonaute proteins can bind small non-coding RNAs and control protein synthesis, affect messenger RNA stability and even participate in the production of a new class of small RNAs, Piwi-interacting RNAs.
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