期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 9, 期 10, 页码 810-815出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2467
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资金
- National Institutes of Health
- Medical Research Council Career Development Award
- MRC [G0700240] Funding Source: UKRI
- Medical Research Council [G0700240] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [R01CA055248, P30CA023108] Funding Source: NIH RePORTER
MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.
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