期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 9, 期 6, 页码 455-463出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2419
关键词
-
类别
资金
- MRC [MC_U105115237] Funding Source: UKRI
Chemotaxis-the guided movement of cells in chemical gradients-probably first emerged in our single-celled ancestors and even today is recognizably similar in neutrophils and amoebae. Chemotaxis enables immune cells to reach sites of infection, allows wounds to heal and is crucial for forming embryonic patterns. Furthermore, the manipulation of chemotaxis may help to alleviate disease states, including the metastasis of cancer cells. This review discusses recent results concerning how cells orientate in chemotactic gradients and the role of phosphatidylinositol-3,4,5-trisphosphate, what produces the force for projecting pseudopodia and a new role for the endocytic cycle in movement.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据