期刊
NATURE REVIEWS MICROBIOLOGY
卷 12, 期 11, 页码 765-771出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3360
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- NIAID NIH HHS [R01 AI084794, U19 AI095985, U19 AI078526, L30 AI061932, U19 AI096040] Funding Source: Medline
The ultimate solution to the global HIV-1 epidemic will probably require the development of a safe and effective vaccine. Multiple vaccine platforms have been evaluated in preclinical and clinical trials, but given the disappointing results of clinical efficacy studies so far, novel vaccine approaches are needed. In this Opinion article, we discuss the scientific basis and clinical potential of novel adenovirus and cytomegalovirus vaccine vectors for HIV-1 as two contrasting but potentially complementary vector approaches. Both of these vector platforms have demonstrated partial protection against stringent simian immunodeficiency virus challenges in rhesus monkeys using different immunological mechanisms.
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