期刊
NATURE REVIEWS MICROBIOLOGY
卷 13, 期 2, 页码 116-123出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3399
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资金
- European Commission [EvoTAR-282004]
- Ministry of Economy and Competitiveness [BIO2011-25255, PI12-01581, PI10-02588, NEXTMICRO]
- Regional Government of Madrid in Spain [PROMPT-S2010/BMD2414]
- Spanish Network for Research on Infectious Diseases [REIPI RD12/0015]
- Spanish Network for the Study of Plasmids and Extrachromosomal Elements (REDEEX) [BFU2011-14145-E]
Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the environment, which has led to the suggestion that there is a high risk that these genes will spread to bacteria that cause human infections. If this is true, estimating the real risk of dissemination of resistance genes from environmental reservoirs to human pathogens is therefore very difficult. In this Opinion article, we analyse the current definitions of antibiotic resistance and antibiotic resistance genes, and we describe the bottlenecks that affect the transfer of antibiotic resistance genes to human pathogens. We propose rules for estimating the risks associated with genes that are present in environmental resistomes by evaluating the likelihood of their introduction into human pathogens, and the consequences of such events for the treatment of infections.
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