期刊
NATURE REVIEWS MICROBIOLOGY
卷 12, 期 11, 页码 729-737出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3349
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资金
- Centre National de la Recherche Scientifique (CNRS)
- FRM
- Agence Nationale de la Recherche (ANR)
- European Union
- Fondation Merieux
- Bettencourt-Schueller Foundation
Several major pathogens, including Mycobacterium tuberculosis, parasitize host cells and exploit host-derived nutrients to sustain their own metabolism. Although the carbon sources that are used by M. tuberculosis have been extensively studied, the mechanisms by which mycobacteria capture and metabolize nitrogen, which is another essential constituent of biomolecules, have only recently been revisited. In this Progress article, we discuss central nitrogen metabolism in M. tuberculosis, the mechanisms that are used by this pathogen to obtain nitrogen from its host and the potential role of nitrogen capture and metabolism in virulence.
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