期刊
NATURE REVIEWS MICROBIOLOGY
卷 12, 期 11, 页码 739-749出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3346
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资金
- US Public Health Service awards [R01 AI76983, R37 AI38296]
- Elizabeth B. Lamb Center for Pediatric Research
Viral infections are initiated by attachment of the virus to host cell surface receptors, including sialic acid-containing glycans. It is now possible to rapidly identify specific glycan receptors using glycan array screening, to define atomic-level structures of virus-glycan complexes and to alter the glycan-binding site to determine the function of glycan engagement in viral disease. This Review highlights general principles of virus-glycan interactions and provides specific examples of sialic acid binding by viruses with stalk-like attachment proteins, including influenza virus, reovirus, adenovirus and rotavirus. Understanding virus-glycan interactions is essential to combating viral infections and designing improved viral vectors for therapeutic applications.
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