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Timothy R. Sampson et al.
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Degenerate target sites mediate rapid primed CRISPR adaptation
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MBIO (2014)
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Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
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BIOCHEMICAL JOURNAL (2013)
Requirements for a successful defence reaction by the CRISPR-Cas subtype I-B system
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Crystal Structure of the Cmr2-Cmr3 Subcomplex in the CRISPR-Cas RNA Silencing Effector Complex
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Conservation and Variability in the Structure and Function of the Cas5d Endoribonuclease in the CRISPR-Mediated Microbial Immune System
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Structure of an RNA Silencing Complex of the CRISPR-Cas Immune System
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Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus
Raymond H. J. Staals et al.
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Structure of the CRISPR Interference Complex CSM Reveals Key Similarities with Cascade
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Same Same but Different: New Structural Insight into CRISPR-Cas Complexes
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A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity
Kimberley D. Seed et al.
NATURE (2013)
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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Revenge of the phages: defeating bacterial defences
Julie E. Samson et al.
NATURE REVIEWS MICROBIOLOGY (2013)
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
David Bikard et al.
NUCLEIC ACIDS RESEARCH (2013)
Comparative genomics of defense systems in archaea and bacteria
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NUCLEIC ACIDS RESEARCH (2013)
Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2
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Rapid evolution of the human gut virome
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Structure and RNA-binding properties of the Type III-A CRISPR-associated protein Csm3
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RNA BIOLOGY (2013)
CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli
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CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance
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Differential Translation Tunes Uneven Production of Operon-Encoded Proteins
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Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands
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PLOS GENETICS (2013)
Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition
Edze R. Westra et al.
PLOS GENETICS (2013)
The CRISPRs, They Are A-Changin': How Prokaryotes Generate Adaptive Immunity
Edze R. Westra et al.
ANNUAL REVIEW OF GENETICS, VOL 46 (2012)
Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
Rachel E. Haurwitz et al.
EMBO JOURNAL (2012)
Crystal structure of Cmr2 suggests a nucleotide cyclase-related enzyme in type III CRISPR-Cas systems
Xing Zhu et al.
FEBS LETTERS (2012)
Characterization of the CRISPR/Cas Subtype I-A System of the Hyperthermophilic Crenarchaeon Thermoproteus tenax
Andre Plagens et al.
JOURNAL OF BACTERIOLOGY (2012)
Crystal Structure of the Largest Subunit of a Bacterial RNA-guided Immune Complex and Its Role in DNA Target Binding
Sabin Mulepati et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Double-stranded Endonuclease Activity in Bacillus halodurans Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Cas2 Protein
Ki Hyun Nam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae
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JOURNAL OF STRUCTURAL BIOLOGY (2012)
Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes From Escherichia coli and Pseudomonas aeruginosa
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MOLECULAR & CELLULAR PROTEOMICS (2012)
Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity
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MOLECULAR CELL (2012)
Essential Features and Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs
Caryn R. Hale et al.
MOLECULAR CELL (2012)
CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3
Edze R. Westra et al.
MOLECULAR CELL (2012)
Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System
Dipali G. Sashital et al.
MOLECULAR CELL (2012)
Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms
Susanne Erdmann et al.
MOLECULAR MICROBIOLOGY (2012)
RNA-guided genetic silencing systems in bacteria and archaea
Blake Wiedenheft et al.
NATURE (2012)
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Ido Yosef et al.
NUCLEIC ACIDS RESEARCH (2012)
Crystal Structure of Streptococcus pyogenes Csn2 Reveals Calcium-Dependent Conformational Changes in Its Tertiary and Quaternary Structure
Yoon Koo et al.
PLOS ONE (2012)
CRISPR Interference Directs Strand Specific Spacer Acquisition
Daan C. Swarts et al.
PLOS ONE (2012)
Cleavage of Phage DNA by the Streptococcus thermophilus CRISPR3-Cas System
Alfonso H. Magadan et al.
PLOS ONE (2012)
In Vivo Protein Interactions and Complex Formation in the Pectobacterium atrosepticum Subtype I-F CRISPR/Cas System
Corinna Richter et al.
PLOS ONE (2012)
Target Motifs Affecting Natural Immunity by a Constitutive CRISPR-Cas System in Escherichia coli
Cristobal Almendros et al.
PLOS ONE (2012)
The CRISPR Associated Protein Cas4 Is a 5′ to 3′ DNA Exonuclease with an Iron-Sulfur Cluster
Jing Zhang et al.
PLOS ONE (2012)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Identification, structural, and biochemical characterization of a group of large Csn2 proteins involved in CRISPR-mediated bacterial immunity
Kwang-Hoon Lee et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2012)
Cascade-mediated binding and bending of negatively supercoiled DNA
Edze R. Westra et al.
RNA BIOLOGY (2012)
Mechanism of substrate selection by a highly specific CRISPR endoribonuclease
Samuel H. Sternberg et al.
RNA (2012)
Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases
Erin L. Garside et al.
RNA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Structure of the Cmr2 Subunit of the CRISPR-Cas RNA Silencing Complex
Alexis I. Cocozaki et al.
STRUCTURE (2012)
Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System
Ki Hyun Nam et al.
STRUCTURE (2012)
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system
Kirill A. Datsenko et al.
NATURE COMMUNICATIONS (2012)
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems
Kira S. Makarova et al.
BIOLOGY DIRECT (2011)
Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference
Natalia Beloglazova et al.
EMBO JOURNAL (2011)
Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system
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EMBO JOURNAL (2011)
The human gut virome: Inter-individual variation and dynamic response to diet
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GENOME RESEARCH (2011)
Crystal Structure of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Csn2 Protein Revealed Ca2+-dependent Double-stranded DNA Binding Activity
Ki Hyun Nam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural and Biochemical Analysis of Nuclease Domain of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Protein 3 (Cas3)
Sabin Mulepati et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair
Mohan Babu et al.
MOLECULAR MICROBIOLOGY (2011)
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
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NATURE (2011)
Structures of the RNA-guided surveillance complex from a bacterial immune system
Blake Wiedenheft et al.
NATURE (2011)
Evolution and classification of the CRISPR-Cas systems
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NATURE REVIEWS MICROBIOLOGY (2011)
Recognition and maturation of effector RNAs in a CRISPR interference pathway
Emily M. Gesner et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Structural basis for CRISPR RNA-guided DNA recognition by Cascade
Matthijs M. Jore et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
Blake Wiedenheft et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence
Ekaterina Semenova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum
Rita Przybilski et al.
RNA BIOLOGY (2011)
Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage
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STRUCTURE (2011)
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ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2010)
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
Josiane E. Garneau et al.
NATURE (2010)
Self versus non-self discrimination during CRISPR RNA-directed immunity
Luciano A. Marraffini et al.
NATURE (2010)
Binding and cleavage of CRISPR RNA by Cas6
Jason Carte et al.
RNA (2010)
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
Rachel E. Haurwitz et al.
SCIENCE (2010)
Self-targeting by CRISPR: gene regulation or autoimmunity?
Adi Stern et al.
TRENDS IN GENETICS (2010)
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
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CELL (2009)
CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties
Reidun K. Lillestol et al.
MOLECULAR MICROBIOLOGY (2009)
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
F. J. M. Mojica et al.
MICROBIOLOGY-SGM (2009)
Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense
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STRUCTURE (2009)
CRISPR-based adaptive and heritable immunity in prokaryotes
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TRENDS IN BIOCHEMICAL SCIENCES (2009)
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes
Jason Carte et al.
GENES & DEVELOPMENT (2008)
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Small CRISPR RNAs guide antiviral defense in prokaryotes
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SCIENCE (2008)
CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
Luciano A. Marraffini et al.
SCIENCE (2008)
Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus
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JOURNAL OF BACTERIOLOGY (2008)
Phage response to CRISPR-Encoded resistance in Streptococcus thermophilus
Helene Deveau et al.
JOURNAL OF BACTERIOLOGY (2008)
Marine viruses - major players in the global ecosystem
Curtis A. Suttle
NATURE REVIEWS MICROBIOLOGY (2007)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
Evolutionary conservation of sequence and secondary structures in CRISPR repeats
Victor Kunin et al.
GENOME BIOLOGY (2007)
Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain
Akio Ebihara et al.
PROTEIN SCIENCE (2006)
The repetitive DNA elements called CRISPRs and their associated genes: Evidence of horizontal transfer among prokaryotes
James S. Godde et al.
JOURNAL OF MOLECULAR EVOLUTION (2006)
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action
Kira S. Makarova et al.
BIOLOGY DIRECT (2006)
A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
DH Haft et al.
PLOS COMPUTATIONAL BIOLOGY (2005)
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
A Bolotin et al.
MICROBIOLOGY-SGM (2005)
The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression
C Maris et al.
FEBS JOURNAL (2005)
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
C Pourcel et al.
MICROBIOLOGY-SGM (2005)
Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
FJM Mojica et al.
JOURNAL OF MOLECULAR EVOLUTION (2005)
Identification of genes that are associated with DNA repeats in prokaryotes
R Jansen et al.
MOLECULAR MICROBIOLOGY (2002)