期刊
NATURE REVIEWS MICROBIOLOGY
卷 11, 期 7, 页码 455-466出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3036
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资金
- NCRR NIH HHS [P51RR00166, P51 RR000166] Funding Source: Medline
- NIAID NIH HHS [HHSN272200800060C, U54AI081680, U54 AI081680] Funding Source: Medline
- NIDA NIH HHS [P30 DA015625, P30DA015625] Funding Source: Medline
- NIH HHS [R24 OD011157, R24 OD011172] Funding Source: Medline
High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.
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