期刊
NATURE REVIEWS MICROBIOLOGY
卷 11, 期 8, 页码 539-550出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3066
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资金
- European Commission [QLK2-CT-2002-01358, GOCE-CT-2003-010284]
- European Union [FP7-261504]
- cademy of Finland
- Sigrid Juselius Foundation
- Magnus Ehrnrooth Foundation
- Helsinki University Central Hospital, Finland
- Tampere University Hospital, Finland
Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of rodents, shrews, moles and bats. Infection in these reservoir hosts is almost asymptomatic, but some rodent-borne hantaviruses also infect humans, causing either haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). In this Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer an overview of virus-induced pathology, in particular vascular leakage and immunopathology.
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