期刊
NATURE REVIEWS MICROBIOLOGY
卷 11, 期 2, 页码 75-82出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2934
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资金
- Pasteur-Weizmann programme
- European Research Council [233348, 260432]
- French Agence Nationale de la Recherche [Bacregrna 09-BLAN-0024-02, BacNet 10-BINF-02-01]
- Fondation Le Roth Les Mousquetaires
- Fondation Louis-Jeantet
- German Minerva Foundation
- Deutsche Forschungsgemeinschaft
- French Institute National de la Recherche Agronomique
- Azrieli Foundation
- European Research Council (ERC) [260432] Funding Source: European Research Council (ERC)
In recent years, non-coding RNAs have emerged as key regulators of gene expression. Among these RNAs, the antisense RNAs (asRNAs) are particularly abundant, but in most cases the function and mechanism of action for a particular asRNA remains elusive. Here, we highlight a recently discovered paradigm termed the excludon, which defines a genomic locus encoding an unusually long asRNA that spans divergent genes or operons with related or opposing functions. Because these asRNAs can inhibit the expression of one operon while functioning as an mRNA for the adjacent operon, they act as fine-tuning regulatory switches in bacteria.
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