期刊
NATURE REVIEWS MICROBIOLOGY
卷 10, 期 7, 页码 459-471出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2801
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资金
- Comprehensive Biomedical Research Centre (cBRC) of Imperial College London, UK
- Asthma UK Fellowship [RF-07_04]
- UK Medical Research Council (MRC) project grant [G0601236]
- European Research Council FP7 Advanced grant [233015]
- Asthma UK Clinical Chair [CH1155]
- MRC Centre grant [G1000758]
- Wellcome Trust strategic and programme grants [090382/Z/09/Z, 083567/Z/07/Z]
- MRC
- MRC [MC_G1001212, G0802752, G0601236, G1100168] Funding Source: UKRI
- Wellcome Trust [090382/Z/09/Z] Funding Source: Wellcome Trust
- Asthma UK [RF07/04, S06/001] Funding Source: researchfish
- Medical Research Council [G1000758B, G1000758, G0802752, G0601236, MC_G1001212, G1100168] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10212] Funding Source: researchfish
Asthma remains an important human disease that is responsible for substantial worldwide morbidity and mortality. The causes of asthma are multifactorial and include a complex mix of environmental, immunological and host genetic factors. In addition, epidemiological studies show strong associations between asthma and infection with respiratory pathogens, including common respiratory viruses such as rhinoviruses, human respiratory syncytial virus, adenoviruses, coronaviruses and influenza viruses, as well as bacteria (including atypical bacteria) and fungi. In this Review, we describe the many roles of microorganisms in the risk of developing asthma and in the pathogenesis of and protection against the disease, and we discuss the mechanisms by which infections affect the severity and prevalence of asthma.
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