期刊
NATURE REVIEWS MICROBIOLOGY
卷 9, 期 3, 页码 215-222出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2508
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资金
- Wellcome Trust, UK
- UK University College London Hospitals NHS Foundation Trust-University College London Comprehensive Biomedical Research Centre
Staphylococcus aureus bacteraemia remains very difficult to treat, and a large proportion of cases result in potentially lethal metastatic infection. Unpredictable and persistent bacteraemia in the face of highly active, usually bactericidal antibiotics is the strongest predictor of death or disseminated disease. Although S. aureus has conventionally been considered an extracellular pathogen, much evidence demonstrates that it can survive intracellularly. In this Opinion article, we propose that phagocytes, and specifically neutrophils, represent a privileged site for S. aureus in the bloodstream, offering protection from most antibiotics and providing a mechanism by which the bacterium can travel to and infect distant sites. Furthermore, we suggest how this can be experimentally confirmed and how it may prompt a change in the current paradigm of S. aureus bacteraemia and identify better treatment options for improved clinical outcomes.
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