期刊
NATURE REVIEWS MICROBIOLOGY
卷 9, 期 4, 页码 291-U1500出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2539
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资金
- US National Institutes of Health [AI080607, CA13854]
- US Southeastern Regional Center of Excellence for Emerging Infections and Biodefense (SERCEB) [U54 AI057157]
- US Bankhead Coley Foundation
The nuclear factor-kappa B (NF-kappa B) family of transcription factors plays a central part in the host response to infection by microbial pathogens, by orchestrating the innate and acquired host immune responses. The NF-kappa B proteins are activated by diverse signalling pathways that originate from many different cellular receptors and sensors. Many successful pathogens have acquired sophisticated mechanisms to regulate the NF-kappa B signalling pathways by deploying subversive proteins or hijacking the host signalling molecules. Here, we describe the mechanisms by which viruses and bacteria micromanage the host NF-kappa B signalling circuitry to favour the continued survival of the pathogen.
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