期刊
NATURE REVIEWS MICROBIOLOGY
卷 8, 期 11, 页码 791-801出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2423
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资金
- US National Aeronautics and Space Administration (NASA) [NCC2-1362, NAG2-1378, NAG 9-1350, NNJ06HE92G, NNX09AH40G]
- US National Institutes of Health [R21MH080702, U19 AI062150-01]
- US Department of Agriculture [2008-35201-04684]
- Science Foundation Arizona [SBC0309-08]
- Belgian American Educational Foundation
- King Baudouin Foundation
- European Space Agency
- Belgian Science Policy
- NIFA [582836, 2008-35201-04684] Funding Source: Federal RePORTER
Appropriately simulating the three-dimensional (3D) environment in which tissues normally develop and function is crucial for engineering in vitro models that can be used for the meaningful dissection of host-pathogen interactions. This Review highlights how the rotating wall vessel bioreactor has been used to establish 3D hierarchical models that range in complexity from a single cell type to multicellular co-culture models that recapitulate the 3D architecture of tissues observed in vivo. The application of these models to the study of infectious diseases is discussed.
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