期刊
NATURE REVIEWS MICROBIOLOGY
卷 8, 期 6, 页码 393-399出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2366
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资金
- Council for Chemical Sciences of the Netherlands Organization for Scientific Research
- US National Institutes of Health
The complement system is a crucial component of the innate immune response in humans. Recent studies in Staphylococcus aureus and Neisseria meningitidis have revealed how these bacteria escape complement-mediated killing. In addition, new structural data have provided detailed insights into the molecular mechanisms of host defence mediated by the complement system and how bacterial proteins interfere with this process. This information is fundamental to our understanding of bacterial pathogenesis and may facilitate the design of better vaccines.
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