期刊
NATURE REVIEWS MICROBIOLOGY
卷 8, 期 3, 页码 231-241出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2296
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资金
- National Institute of Allergy and Infectious Diseases
- US National Institutes of Health [AID56351]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI056351] Funding Source: NIH RePORTER
Noroviruses are the most common cause of food-borne gastroenteritis worldwide, and explosive outbreaks frequently occur in community settings, where the virus can immobilize large numbers of infected individuals for 24-48 hours, making the development of effective vaccines and antiviral therapies a priority. However, several challenges have hampered therapeutic design, including: the limitations of cell culture and small-animal model systems; the complex effects of host pre-exposure histories; differential host susceptibility, which is correlated with blood group and secretor status; and the evolution of novel immune escape variants. In this Review, we discuss the molecular and structural mechanisms that facilitate the persistence of noroviruses in human populations.
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