期刊
NATURE REVIEWS MICROBIOLOGY
卷 7, 期 10, 页码 736-747出版社
NATURE RESEARCH
DOI: 10.1038/nrmicro2208
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资金
- Institut Pasteur
- Oswaldo Cruz Foundation
- Brazilian National Research Council [01.06.0298.00, 3773/2005, 554788/2006]
- Research Support Foundation for the State of Bahia [54663]
- National Institutes of Health [2R01 AI052473, 2D43 TW00919]
- Institut Pasteur and by Agence Nationale de la Recherche [05-JCJC-0105-01]
- FOGARTY INTERNATIONAL CENTER [D43TW000919] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI052473] Funding Source: NIH RePORTER
Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis.
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