期刊
NATURE REVIEWS MICROBIOLOGY
卷 7, 期 9, 页码 629-641出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2200
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资金
- National Institute of Allergy and Infectious Disease (NIAID)
- National Institutes of Health (NIH) [R01 AI070289]
Staphylococcus aureus is notorious for its ability to become resistant to antibiotics. Infections that are caused by antibiotic-resistant strains often occur in epidemic waves that are initiated by one or a few successful clones. Methicillin-resistant S. aureus (MRSA) features prominently in these epidemics. Historically associated with hospitals and other health care settings, MRSA has now emerged as a widespread cause of community infections. Community or community-associated MRSA (CA-MRSA) can spread rapidly among healthy individuals. Outbreaks of CA-MRSA infections have been reported worldwide, and CA-MRSA strains are now epidemic in the United States. Here, we review the molecular epidemiology of the epidemic waves of penicillin-and methicillin-resistant strains of S. aureus that have occurred since 1940, with a focus on the clinical and molecular epidemiology of CA-MRSA.
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