期刊
NATURE REVIEWS MICROBIOLOGY
卷 7, 期 3, 页码 226-236出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro2090
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资金
- National Institutes of Health (NIH) [RO1 AI68002]
- Research Fund for the Control of Infectious Diseases
- Food and Health Bureau of the Hong Kong SAR Government
- National 973 Basic Research Program of China [2005CB523001]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI068002] Funding Source: NIH RePORTER
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike ( S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.
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